| First Author | Grillo FW | Year | 2018 |
| Journal | Neuron | Volume | 99 |
| Issue | 2 | Pages | 275-282.e3 |
| PubMed ID | 29983327 | Mgi Jnum | J:269403 |
| Mgi Id | MGI:6268989 | Doi | 10.1016/j.neuron.2018.06.015 |
| Citation | Grillo FW, et al. (2018) A Distance-Dependent Distribution of Presynaptic Boutons Tunes Frequency-Dependent Dendritic Integration. Neuron 99(2):275-282.e3 |
| abstractText | How presynaptic inputs and neurotransmitter release dynamics are distributed along a dendritic tree is not well established. Here, we show that presynaptic boutons that form onto basal dendrites of CA1 pyramidal neurons display a decrease in active zone (AZ) size with distance from the soma, resulting in a distance-dependent increase in short-term facilitation. Our findings suggest that the spatial distribution of short-term facilitation serves to compensate for the electrotonic attenuation of subthreshold distal inputs during repeated stimulation and fine-tunes the preferred input frequency of dendritic domains. |
