| First Author | Popp RA | Year | 1977 |
| Journal | Am J Vet Res | Volume | 38 |
| Issue | 5 | Pages | 569-72 |
| PubMed ID | 879556 | Mgi Jnum | J:123943 |
| Mgi Id | MGI:3720008 | Citation | Popp RA, et al. (1977) Radiation-induced alpha-thalassemia in mice. Am J Vet Res 38(5):569-72 |
| abstractText | The clinical hematologic change in 2 groups of progeny from mice carrying radiation-induced strain SEC alpha-chain deficiencies was found to be similar to the hematologic alterations in persons with alpha-thalassemia. The heterozygous deletion or inactivation of the alpha-chain gene in mice caused an anemia similar to alpha-thalassemina minor in persons. The alpha-chain deficiency in mice created an erythrocytosis, reticulocytosis, and microcytic, hypochromic anemia comparable with the changes in human alpha-thalassemia minor resulting from deletion of the alpha-chain gene. These mouse mutants are the only known animal models of human thalassemia. A comparison of hematologic values obtained from progeny possessing an alpha-chain gene deficiency and from progeny possessing a beta-chain duplication suggested that the deficiency of alpha-chain synthesis, rather than a simple imbalance between the amounts of alpha- and beta-chains produced, was primarily responsible for the altered hematologic characteristics in these alpha-thalassemic mice. |
