| Primary Identifier | MGI:2678007 | Allele Type | QTL |
| Gene | Tmevd1 | Inheritance Mode | Not Specified |
| Strain of Origin | DBA/2J | Is Recombinase | false |
| Is Wild Type | false |
| description | This is a susceptibility allele (J:43978). Theiler's murine encephalomyelitis virus (TMEV) is a normal enteric pathogen in wild and laboratory mice which causes no clinical symptoms unless introduced into the central nervous system (CNS). In the CNS, however, a chronic low-grade infection is established which causes an immune response leading to CNS demyelination. Genetic analysis between susceptible SJL/J and resistant C57BL/6J mice indicated a major role of the H2-D1 region. Between the susceptible SJL/J and resistant BALB/c mice, there does not appear to be an effect of the major histocompatibility complex, but at least two non-H2 loci are involved (J:8573). |
