| Primary Identifier | MGI:2678314 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Top1 |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A neomycin selection cassette replaced a genomic fragment containing exon 15. Western blot analysis demonstrated that a 45% reduction of encoded protein levels was present in cells derived from heterozygous mice. Cytological analysis of early homozygous mutant embryos demonstrated that no detectable protein was produced from this allele. |
