| First Author | Tordoff MG | Year | 2017 |
| Journal | Chem Senses | Volume | 42 |
| Issue | 5 | Pages | 425-433 |
| PubMed ID | 28383662 | Mgi Jnum | J:272797 |
| Mgi Id | MGI:6282449 | Doi | 10.1093/chemse/bjx019 |
| Citation | Tordoff MG (2017) Phosphorus Taste Involves T1R2 and T1R3. Chem Senses 42(5):425-433 |
| abstractText | Rodents consume solutions of phosphates and pyrophosphates in preference to water. Recently, we found that the preference for trisodium pyrophosphate (Na3HP2O7) was greater in T1R3 knockout (KO) mice than wild-type (WT) controls, suggesting that T1R3 is a pyrophosphate detector. We now show that this heightened Na3HP2O7 preference of T1R3 KO mice extends to disodium phosphate (Na2HPO4), disodium and tetrasodium pyrophosphate (Na2H2PO4 and Na4H2PO4), a tripolyphosphate (Na5P3O10), a non-sodium phosphate [(NH4)2HPO4], and a non-sodium pyrophosphate (K4P2O7) but not to non-P salts with large anions (sodium gluconate, acetate, or propionate). Licking rates for Na3HP2O7 are higher in T1R2 KO mice than WT controls; Na3HP2O7 preference scores are increased even more in T1R2 KO mice and T1R2+T1R3 double KO mice than in T1R3 KO mice; preference scores for Na3HP2O7 are normal in T1R1 KO mice. These results implicate each subunit of the T1R2+T1R3 dimer in the behavioral response to P-containing taste compounds. |
