| First Author | Takaoka A | Year | 2000 |
| Journal | Science | Volume | 288 |
| Issue | 5475 | Pages | 2357-60 |
| PubMed ID | 10875919 | Mgi Jnum | J:85824 |
| Mgi Id | MGI:2677098 | Doi | 10.1126/science.288.5475.2357 |
| Citation | Takaoka A, et al. (2000) Cross talk between interferon-gamma and -alpha/beta signaling components in caveolar membrane domains. Science 288(5475):2357-60 |
| abstractText | Definition of cellular responses to cytokines often involves cross-communication through their respective receptors. Here, signaling by interferon-gamma (IFN-gamma) is shown to depend on the IFN-alpha/beta receptor components. Although these IFNs transmit signals through distinct receptor complexes, the IFN-alpha/beta receptor component, IFNAR1, facilitates efficient assembly of IFN-gamma-activated transcription factors. This cross talk is contingent on a constitutive subthreshold IFN-alpha/beta signaling and the association between the two nonligand-binding receptor components, IFNAR1 and IFNGR2, in the caveolar membrane domains. This aspect of signaling cross talk by IFNs may apply to other cytokines. |
