| First Author | Reale C | Year | 2016 |
| Journal | J Biol Chem | Volume | 291 |
| Issue | 11 | Pages | 5765-73 |
| PubMed ID | 26786105 | Mgi Jnum | J:231227 |
| Mgi Id | MGI:5770017 | Doi | 10.1074/jbc.M115.711697 |
| Citation | Reale C, et al. (2016) NF-kappaB Essential Modulator (NEMO) Is Critical for Thyroid Function. J Biol Chem 291(11):5765-73 |
| abstractText | The I-kappaB kinase (IKK) subunit NEMO/IKKgamma (NEMO) is an adapter molecule that is critical for canonical activation of NF-kappaB, a pleiotropic transcription factor controlling immunity, differentiation, cell growth, tumorigenesis, and apoptosis. To explore the functional role of canonical NF-kappaB signaling in thyroid gland differentiation and function, we have generated a murine strain bearing a genetic deletion of the NEMO locus in thyroid. Here we show that thyrocyte-specific NEMO knock-out mice gradually develop hypothyroidism after birth, which leads to reduced body weight and shortened life span. Histological and molecular analysis indicate that absence of NEMO in thyrocytes results in a dramatic loss of the thyroid gland cellularity, associated with down-regulation of thyroid differentiation markers and ongoing apoptosis. Thus, NEMO-dependent signaling is essential for normal thyroid physiology. |
