| First Author | Ramos JW | Year | 2009 |
| Journal | BMC Neurosci | Volume | 10 |
| Pages | 134 | PubMed ID | 19917132 |
| Mgi Jnum | J:226152 | Mgi Id | MGI:5695842 |
| Doi | 10.1186/1471-2202-10-134 | Citation | Ramos JW, et al. (2009) Deletion of PEA-15 in mice is associated with specific impairments of spatial learning abilities. BMC Neurosci 10:134 |
| abstractText | BACKGROUND: PEA-15 is a phosphoprotein that binds and regulates ERK MAP kinase and RSK2 and is highly expressed throughout the brain. PEA-15 alters c-Fos and CREB-mediated transcription as a result of these interactions. To determine if PEA-15 contributes to the function of the nervous system we tested mice lacking PEA-15 in a series of experiments designed to measure learning, sensory/motor function, and stress reactivity. RESULTS: We report that PEA-15 null mice exhibited impaired learning in three distinct spatial tasks, while they exhibited normal fear conditioning, passive avoidance, egocentric navigation, and odor discrimination. PEA-15 null mice also had deficient forepaw strength and in limited instances, heightened stress reactivity and/or anxiety. However, these non-cognitive variables did not appear to account for the observed spatial learning impairments. The null mice maintained normal weight, pain sensitivity, and coordination when compared to wild type controls. CONCLUSION: We found that PEA-15 null mice have spatial learning disabilities that are similar to those of mice where ERK or RSK2 function is impaired. We suggest PEA-15 may be an essential regulator of ERK-dependent spatial learning. |
