| First Author | Chung A | Year | 2017 |
| Journal | Learn Mem | Volume | 24 |
| Issue | 12 | Pages | 646-649 |
| PubMed ID | 29142061 | Mgi Jnum | J:273967 |
| Mgi Id | MGI:6282086 | Doi | 10.1101/lm.045617.117 |
| Citation | Chung A, et al. (2017) Effects of regulatory BC1 RNA deletion on synaptic plasticity, learning, and memory. Learn Mem 24(12):646-649 |
| abstractText | Nonprotein coding dendritic BC1 RNA regulates translation of mRNAs in neurons. We examined two lines of BC1 knockout mice and report that loss of BC1 RNA exaggerates group I mGluR-stimulated LTD of the Schaffer collateral synapse, with one of the lines showing a much more enhanced DHPG-induced LTD than the other. When the animals were given the hippocampus-synaptic plasticity-dependent active place avoidance task, learning and memory were impaired in the BC1-KO line with the more severely altered DHPG-induced LTD. These findings indicate a role for BC1 RNA control of mGluR-dependent synaptic function in hippocampus and associated cognitive ability. |
