| First Author | Smith L | Year | 2008 |
| Journal | Gene Expr Patterns | Volume | 8 |
| Issue | 7-8 | Pages | 486-93 |
| PubMed ID | 18639653 | Mgi Jnum | J:138322 |
| Mgi Id | MGI:3804785 | Doi | 10.1016/j.gep.2008.06.006 |
| Citation | Smith L, et al. (2008) uPARAP expression during murine lung development. Gene Expr Patterns 8(7-8):486-93 |
| abstractText | Lung remodeling requires active collagen deposition and degradation. Urokinase plasminogen activator receptor-associated protein (uPARAP), or Endo 180, is a cell-surface receptor for collagens, which leads to collagen internalization and degradation. Thus, uPARAP-mediated collagen degradation is an additional pathway for matrix remodeling in addition to matrix remodeling mediated by matrix metalloproteinases and cathepsins. Using immunohistochemistry, we demonstrate extensive uPARAP expression in the mesenchyme throughout murine lung development. By immunofluorescence, we demonstrate significant overlap of uPARAP expression with collagen IV expression, but minimal overlap with collagen I expression in the developing murine lung. Finally, we compared lung development between wild-type and uPARAP(-/-) mice, and found no significant histologic differences, indicating the presence of alternative collagen degradation pathways during murine lung development. |
