| First Author | Clark AJ | Year | 2000 |
| Journal | Transgenic Res | Volume | 9 |
| Issue | 6 | Pages | 439-44 |
| PubMed ID | 11206972 | Mgi Jnum | J:67084 |
| Mgi Id | MGI:1929826 | Doi | 10.1023/a:1026552629493 |
| Citation | Clark AJ, et al. (2000) Deletion of the gene encoding H-FABP/MDGI has no overt effects in the mammary gland. Transgenic Res 9(6):439-44 |
| abstractText | Heart fatty acid binding protein (H-FABP) is expressed abundantly in the mammary gland. A number of in vitro studies have shown that H-FABP is functionally indistinguishable from a factor isolated from this organ, termed mammary derived growth inhibitor (MDGI), which specifically inhibits the proliferation of mammary tissue. We have previously shown that over-expression of H-FABP/MDGI in the mammary gland of transgenic mice has no discernable effects on cell proliferation or differentiation. In this report we describe knockout mouse in which the H-FABP/MDGI gene has been specifically disrupted. The mice exhibit no overt phenotype in the mammary gland, and we conclude that this gene does not play a specific role in regulating the normal development or function of this tissue. |
