| First Author | Kobayashi S | Year | 2021 |
| Journal | FEBS J | Volume | 288 |
| Issue | 4 | Pages | 1130-1141 |
| PubMed ID | 32578350 | Mgi Jnum | J:329350 |
| Mgi Id | MGI:6755371 | Doi | 10.1111/febs.15460 |
| Citation | Kobayashi S, et al. (2021) Fatty acid-binding protein 3 regulates differentiation of IgM-producing plasma cells. FEBS J 288(4):1130-1141 |
| abstractText | Plasma cells (PCs), which aim to protect host health, produce various subsets of immunoglobulin (Ig) in response to extracellular pathogens. Blimp-1 (encoded by Prdm1)-a protein that is highly expressed by PCs-is important for PC functions, including the generation of Igs. Fatty acid-binding protein 3 (FABP3) is a carrier protein of polyunsaturated fatty acids (PUFAs) and participates in multiple cellular functions. Although the functions of FABP3 in neurons and cardiac myocytes are well-noted, their roles in immune cells remain to be fully elucidated. In this study, we demonstrate that FABP3 is expressed in activated B cells and that FABP3 promotes PC development and IgM secretion. Moreover, we provide the first evidence that FABP3 is necessary for Blimp-1 expression, by regulating the histone modification of its promoter region. Taken together, our findings reveal that FABP3 acts as a positive regulator of B-cell activation by controlling histone acetylation of the Blimp-1 gene, thereby playing a role in host defense against pathogens. |
