| First Author | Capucha T | Year | 2018 |
| Journal | J Exp Med | Volume | 215 |
| Issue | 2 | Pages | 481-500 |
| PubMed ID | 29343501 | Mgi Jnum | J:257583 |
| Mgi Id | MGI:6119837 | Doi | 10.1084/jem.20171508 |
| Citation | Capucha T, et al. (2018) Sequential BMP7/TGF-beta1 signaling and microbiota instruct mucosal Langerhans cell differentiation. J Exp Med 215(2):481-500 |
| abstractText | Mucosal Langerhans cells (LCs) originate from pre-dendritic cells and monocytes. However, the mechanisms involved in their in situ development remain unclear. Here, we demonstrate that the differentiation of murine mucosal LCs is a two-step process. In the lamina propria, signaling via BMP7-ALK3 promotes translocation of LC precursors to the epithelium. Within the epithelium, TGF-beta1 finalizes LC differentiation, and ALK5 is crucial to this process. Moreover, the local microbiota has a major impact on the development of mucosal LCs, whereas LCs in turn maintain mucosal homeostasis and prevent tissue destruction. These results reveal the differential and sequential role of TGF-beta1 and BMP7 in LC differentiation and highlight the intimate interplay of LCs with the microbiota. |
