| First Author | Mercken EM | Year | 2014 |
| Journal | Aging Cell | Volume | 13 |
| Issue | 5 | Pages | 787-96 |
| PubMed ID | 24931715 | Mgi Jnum | J:220725 |
| Mgi Id | MGI:5635980 | Doi | 10.1111/acel.12220 |
| Citation | Mercken EM, et al. (2014) SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass. Aging Cell 13(5):787-96 |
| abstractText | Increased expression of SIRT1 extends the lifespan of lower organisms and delays the onset of age-related diseases in mammals. Here, we show that SRT2104, a synthetic small molecule activator of SIRT1, extends both mean and maximal lifespan of mice fed a standard diet. This is accompanied by improvements in health, including enhanced motor coordination, performance, bone mineral density, and insulin sensitivity associated with higher mitochondrial content and decreased inflammation. Short-term SRT2104 treatment preserves bone and muscle mass in an experimental model of atrophy. These results demonstrate it is possible to design a small molecule that can slow aging and delay multiple age-related diseases in mammals, supporting the therapeutic potential of SIRT1 activators in humans. |
