| First Author | Shoji M | Year | 2012 |
| Journal | Biochem Biophys Res Commun | Volume | 425 |
| Issue | 1 | Pages | 89-93 |
| PubMed ID | 22819843 | Mgi Jnum | J:187167 |
| Mgi Id | MGI:5435628 | Doi | 10.1016/j.bbrc.2012.07.056 |
| Citation | Shoji M, et al. (2012) Type-I IFN signaling is required for the induction of antigen-specific CD8(+) T cell responses by adenovirus vector vaccine in the gut-mucosa. Biochem Biophys Res Commun 425(1):89-93 |
| abstractText | Adenovirus vector (Adv) vaccination at a systemic site, such as intramuscular (i.m.) immunization, can induce antigen-specific CD8(+) T cell responses in both systemic and mucosal compartments. It remains unclear, however, how antigen-specific CD8(+) T cell response is induced in the mucosa. In this study, we found that type-I IFN signaling is required for the induction of mRNA expression of retinal dehydrogenase in the draining lymph nodes following the i.m. Adv vaccination. We show that type-I IFN signaling is required for the induction of antigen-specific CD8(+) T cell response in the gut-mucosal compartment following the i.m. Adv vaccination. |
