Other
13 Authors
- Nakamura Y,
- Ono M,
- Lu LM,
- Terada M,
- Onji M,
- Nozaki Y,
- Hata K,
- Nose M,
- Yamada A,
- Miyazaki T,
- Mori S,
- Nakatsuru S,
- Ito MR
| First Author | Yamada A | Year | 2003 |
| Journal | Arthritis Rheum | Volume | 48 |
| Issue | 5 | Pages | 1445-51 |
| PubMed ID | 12746919 | Mgi Jnum | J:83832 |
| Mgi Id | MGI:2663816 | Doi | 10.1002/art.10952 |
| Citation | Yamada A, et al. (2003) Genetic basis of tissue specificity of vasculitis in MRL/lpr mice. Arthritis Rheum 48(5):1445-51 |
| abstractText | OBJECTIVE: To clarify the mode of inheritance of the tissue distribution of vasculitis in MRL/Mp-lpr/lpr (MRL/lpr) lupus-prone mice and to identify the susceptibility loci. METHODS: Vasculitis in individual MRL/lpr, C3H/HeJ-lpr/lpr (C3H/lpr), (MRL/lpr x C3H/lpr)F(1), and (MRL/lpr x C3H/lpr)F(2) intercross mice was analyzed by histopathologic grading of main branches of the aorta and of medium-sized arteries in the lower limbs. Genomic DNA samples from F(2) intercross mice were examined by simple sequence-length polymorphism analysis, and the polymorphic microsatellite markers highly associated with vasculitis in each tissue were determined as vasculitis susceptibility loci. RESULTS: A susceptibility locus with significant linkage to vasculitis of main branches of the aorta was mapped on chromosome 4 at D4Mit213 (map position 13.3cM) selectively in males, while vasculitis of medium-sized arteries in the lower limbs was mapped to different chromosomes: at D8Mit31 on chromosome 8 (map position 33.0) selectively in females and at D5Mit36 on chromosome 5 (map position 65.0). All of these were different from the previously defined loci governing susceptibility to vasculitis involving the kidneys. CONCLUSION: Systemic vasculitis in MRL/lpr mice is genetically controlled with cumulative effects of multiple gene loci, each of which has tissue specificity. |
