| First Author | Alam MM | Year | 2022 |
| Journal | Cell Rep | Volume | 38 |
| Issue | 2 | Pages | 110090 |
| PubMed ID | 35021075 | Mgi Jnum | J:320659 |
| Mgi Id | MGI:6874531 | Doi | 10.1016/j.celrep.2021.110090 |
| Citation | Alam MM, et al. (2022) Alpha synuclein, the culprit in Parkinson disease, is required for normal immune function. Cell Rep 38(2):110090 |
| abstractText | Alpha-synuclein (alphaS) is causally involved in the development of Parkinson disease (PD); however, its role in normal vertebrate physiology has remained unknown. Recent studies demonstrate that alphaS is induced by noroviral infection in the enteric nervous system of children and protects mice against lethal neurotropic viral infection. Additionally, alphaS is a potent chemotactic activator of phagocytes. In this report, using both wild-type and alphaS knockout mice, we show that alphaS is a critical mediator of inflammatory and immune responses. alphaS is required for the development of a normal inflammatory response to bacterial peptidoglycan introduced into the peritoneal cavity as well as antigen-specific and T cell responses following intraperitoneal immunization. Furthermore, we show that neural cells are the sources of alphaS required for immune competence. Our report supports the hypothesis that alphaS accumulates within the nervous system of PD individuals because of an inflammatory/immune response. |
