| First Author | Apostolou I | Year | 2002 |
| Journal | Nat Immunol | Volume | 3 |
| Issue | 8 | Pages | 756-63 |
| PubMed ID | 12089509 | Mgi Jnum | J:126449 |
| Mgi Id | MGI:3761259 | Doi | 10.1038/ni816 |
| Citation | Apostolou I, et al. (2002) Origin of regulatory T cells with known specificity for antigen. Nat Immunol 3(8):756-63 |
| abstractText | T cell receptor agonists can induce the differentiation of regulatory T (T(R)) cells. We report here that the immunoglobulin kappa-controlled expression of an agonist in different cell types correlated with the phenotype of the generated T(R) cells. We found that aberrant expression on thymic stroma yielded predominantly CD4(+)CD25(+) T(R) cells, which--under physiological conditions--may be induced by ectopically expressed organ-specific antigens and thus prevent organ-specific autoimmunity. Expression of the agonist antigen by nonactivated hematopoietic cells produced mostly CD4(+)CD25(-) T(R) cells. This subset can be derived from mature monospecific T cells without 'tutoring' by other T cells and can be generated in the absence of a functioning thymus. Suppression of CD4(+) T cell proliferative responses by both CD25(+) and CD25(-) subsets was interleukin 10 (IL-10) independent and was overcome by IL-2. These data suggest that distinct pathways can be exploited to interfere with unwanted immune responses. |
