| First Author | Picca CC | Year | 2009 |
| Journal | Eur J Immunol | Volume | 39 |
| Issue | 12 | Pages | 3301-6 |
| PubMed ID | 19768697 | Mgi Jnum | J:155491 |
| Mgi Id | MGI:4414608 | Doi | 10.1002/eji.200939709 |
| Citation | Picca CC, et al. (2009) Thymocyte deletion can bias Treg formation toward low-abundance self-peptide. Eur J Immunol 39(12):3301-6 |
| abstractText | Autoreactive CD4+ T cells can undergo deletion and/or become CD25+Foxp3+ Treg as they develop intrathymically, but how these alternative developmental fates are specified based on interactions with self-peptide(s) is not understood. We show here that thymocytes expressing an autoreactive TCR can be subjected to varying degrees of deletion that correlate with the amount of self-peptide. Strikingly, among thymocytes that evade deletion, similar proportions acquire Foxp3 expression. These findings provide evidence that Foxp3+ Treg can develop among members of a cohort of autoreactive thymocytes that have evaded deletion by a self-peptide, and that deletion and Treg formation can act together to bias the Treg repertoire toward low-abundance self-peptide(s). |
