| First Author | Tanchot C | Year | 2004 |
| Journal | J Immunol | Volume | 172 |
| Issue | 7 | Pages | 4285-91 |
| PubMed ID | 15034042 | Mgi Jnum | J:88728 |
| Mgi Id | MGI:3036963 | Doi | 10.4049/jimmunol.172.7.4285 |
| Citation | Tanchot C, et al. (2004) Immune regulation by self-reactive T cells is antigen specific. J Immunol 172(7):4285-91 |
| abstractText | Immune regulation plays an important role in the establishment and maintenance of self-tolerance. Nevertheless, it has been difficult to conclude whether regulation is Ag specific because studies have focused on polyclonal populations of regulatory T cells. We have used in this study a murine transgenic model that generates self-reactive, regulatory T cells of known Ag specificity to determine their capacity to suppress naive T cells specific for other Ags. We show that these regulatory cells can regulate the responses of naive T cells with the same TCR specificity, but do not inhibit T cell proliferation or differentiation of naive T cells specific for other Ags. These results demonstrate that immune regulation may be more Ag specific than previously proposed. |
