| First Author | Dawson PA | Year | 2004 |
| Journal | Behav Brain Res | Volume | 154 |
| Issue | 2 | Pages | 457-63 |
| PubMed ID | 15313034 | Mgi Jnum | J:92319 |
| Mgi Id | MGI:3052386 | Doi | 10.1016/j.bbr.2004.03.013 |
| Citation | Dawson PA, et al. (2004) Behavioural abnormalities of the hyposulphataemic Nas1 knock-out mouse. Behav Brain Res 154(2):457-63 |
| abstractText | We recently generated a sodium sulphate cotransporter knock-out mouse (Nas1-/-) which has increased urinary sulphate excretion and hyposulphataemia. To examine the consequences of disturbed sulphate homeostasis in the modulation of mouse behavioural characteristics, Nas1-/- mice were compared with Nas1+/- and Nas1+/+ littermates in a series of behavioural tests. The Nas1-/- mice displayed significantly ( [Formula: see text] ) decreased marble burying behaviour ( [Formula: see text] buried) when compared to Nas1+/+ ( [Formula: see text] ) and Nas1+/- ( [Formula: see text] ) animals, suggesting that Nas1-/- mice may have decreased object-induced anxiety. The Nas1-/- mice also displayed decreased locomotor activity by moving less distance ( [Formula: see text] m, [Formula: see text] ) in an open-field test when compared to Nas1+/+ ( [Formula: see text] m) and Nas1+/- ( [Formula: see text] m) mice. The three genotypes displayed similar spatiotemporal and ethological behaviours in the elevated-plus maze and open-field test, with the exception of a decreased defecation frequency by the Nas1-/- mice (40% reduction, [Formula: see text] ). There were no significant differences between Nas1-/- and Nas1+/+ mice in a rotarod performance test of motor coordination and in the forced swim test assessing (anti-)depressant-like behaviours. This is the first study to demonstrate behavioural abnormalities in the hyposulphataemic Nas1-/- mice. |
