| First Author | Dawson PA | Year | 2011 |
| Journal | J Reprod Dev | Volume | 57 |
| Issue | 4 | Pages | 444-9 |
| PubMed ID | 21403420 | Mgi Jnum | J:345448 |
| Mgi Id | MGI:7606368 | Doi | 10.1262/jrd.10-173k |
| Citation | Dawson PA, et al. (2011) Fetal loss and hyposulfataemia in pregnant NaS1 transporter null mice. J Reprod Dev 57(4):444-9 |
| abstractText | Sulfate is important for growth and development, and is supplied from mother to fetus throughout pregnancy. We used NaS1 sulfate transporter null (Nas1(-/-)) mice to investigate the role of NaS1 in maintaining sulfate homeostasis during pregnancy and to determine the physiological consequences of maternal hyposulfataemia on fetal, placental and postnatal growth. We show that maternal serum (</=0.5 mM), fetal serum (<0.1 mM) and amniotic fluid (</=0.5 mM) sulfate levels were significantly lower in pregnant Nas1(-/-) mice when compared with maternal serum ( asymptotically equal to2.0 mM), fetal serum ( asymptotically equal to1.5 mM) and amniotic fluid ( asymptotically equal to1.7 mM) sulfate levels in pregnant Nas1(+/+) mice. After 12 days of pregnancy, fetal reabsorptions led to markedly reduced (by >/=50%) fetal numbers in Nas1(-/-) mice. Placental labyrinth and spongiotrophoblast layers were increased (by asymptotically equal to140%) in pregnant Nas1(-/-) mice when compared to pregnant Nas1(+/+) mice. Birth weights of progeny from female Nas1(-/-) mice were increased (by asymptotically equal to7%) when compared to progeny of Nas1(+/+) mice. These findings show that NaS1 is essential to maintain high maternal and fetal sulfate levels, which is important for maintaining pregnancy, placental development and normal birth weight. |
