| First Author | Pereira M | Year | 2016 |
| Journal | Nat Commun | Volume | 7 |
| Pages | 12874 | PubMed ID | 27670879 |
| Mgi Jnum | J:242368 | Mgi Id | MGI:5905093 |
| Doi | 10.1038/ncomms12874 | Citation | Pereira M, et al. (2016) CARD9 negatively regulates NLRP3-induced IL-1beta production on Salmonella infection of macrophages. Nat Commun 7:12874 |
| abstractText | Interleukin-1beta (IL-1beta) is a proinflammatory cytokine required for host control of bacterial infections, and its production must be tightly regulated to prevent excessive inflammation. Here we show that caspase recruitment domain-containing protein 9 (CARD9), a protein associated with induction of proinflammatory cytokines by fungi, has a negative role on IL-1beta production during bacterial infection. Specifically, in response to activation of the nucleotide oligomerization domain receptor pyrin-domain containing protein 3 (NLRP3) by Salmonella infection, CARD9 negatively regulates IL-1beta by fine-tuning pro-IL-1beta expression, spleen tyrosine kinase (SYK)-mediated NLRP3 activation and repressing inflammasome-associated caspase-8 activity. CARD9 is suppressed during Salmonella enterica serovar Typhimurium infection, facilitating increased IL-1beta production. CARD9 is, therefore, a central signalling hub that coordinates a pathogen-specific host inflammatory response. |
