| First Author | Bernstein E | Year | 2003 |
| Journal | Nat Genet | Volume | 35 |
| Issue | 3 | Pages | 215-7 |
| PubMed ID | 14528307 | Mgi Jnum | J:86391 |
| Mgi Id | MGI:2679763 | Doi | 10.1038/ng1253 |
| Citation | Bernstein E, et al. (2003) Dicer is essential for mouse development. Nat Genet 35(3):215-7 |
| abstractText | To address the biological function of RNA interference (RNAi)-related pathways in mammals, we disrupted the gene Dicer1 in mice. Loss of Dicer1 lead to lethality early in development, with Dicer1-null embryos depleted of stem cells. Coupled with our inability to generate viable Dicer1-null embryonic stem (ES) cells, this suggests a role for Dicer, and, by implication, the RNAi machinery, in maintaining the stem cell population during early mouse development. |
