| First Author | Rushing GV | Year | 2019 |
| Journal | Life Sci Alliance | Volume | 2 |
| Issue | 2 | PubMed ID | 30910807 |
| Mgi Jnum | J:286086 | Mgi Id | MGI:6391956 |
| Doi | 10.26508/lsa.201800218 | Citation | Rushing GV, et al. (2019) Location-dependent maintenance of intrinsic susceptibility to mTORC1-driven tumorigenesis. Life Sci Alliance 2(2) |
| abstractText | Neural stem/progenitor cells (NSPCs) of the ventricular-subventricular zone (V-SVZ) are candidate cells of origin for many brain tumors. However, whether NSPCs in different locations within the V-SVZ differ in susceptibility to tumorigenic mutations is unknown. Here, single-cell measurements of signal transduction intermediates in the mechanistic target of rapamycin complex 1 (mTORC1) pathway reveal that ventral NSPCs have higher levels of signaling than dorsal NSPCs. These features are linked with differences in mTORC1-driven disease severity: introduction of a pathognomonic Tsc2 mutation only results in formation of tumor-like masses from the ventral V-SVZ. We propose a direct link between location-dependent intrinsic growth properties imbued by mTORC1 and predisposition to tumor development. |
