| First Author | Wu YW | Year | 2015 |
| Journal | Cell Rep | Volume | 10 |
| Issue | 1 | Pages | 75-87 |
| PubMed ID | 25543142 | Mgi Jnum | J:350648 |
| Mgi Id | MGI:6274097 | Doi | 10.1016/j.celrep.2014.12.005 |
| Citation | Wu YW, et al. (2015) Input- and cell-type-specific endocannabinoid-dependent LTD in the striatum. Cell Rep 10(1):75-87 |
| abstractText | Changes in basal ganglia plasticity at the corticostriatal and thalamostriatal levels are required for motor learning. Endocannabinoid-dependent long-term depression (eCB-LTD) is known to be a dominant form of synaptic plasticity expressed at these glutamatergic inputs; however, whether eCB-LTD can be induced at all inputs on all striatal neurons is still debatable. Using region-specific Cre mouse lines combined with optogenetic techniques, we directly investigated and distinguished between corticostriatal and thalamostriatal projections. We found that eCB-LTD was successfully induced at corticostriatal synapses, independent of postsynaptic striatal spiny projection neuron (SPN) subtype. Conversely, eCB-LTD was only nominally present at thalamostriatal synapses. This dichotomy was attributable to the minimal expression of cannabinoid type 1 (CB1) receptors on thalamostriatal terminals. Furthermore, coactivation of dopamine receptors on SPNs during LTD induction re-established SPN-subtype-dependent eCB-LTD. Altogether, our findings lay the groundwork for understanding corticostriatal and thalamostriatal synaptic plasticity and for striatal eCB-LTD in motor learning. |
