| First Author | Rudra D | Year | 2012 |
| Journal | Nat Immunol | Volume | 13 |
| Issue | 10 | Pages | 1010-9 |
| PubMed ID | 22922362 | Mgi Jnum | J:187701 |
| Mgi Id | MGI:5437802 | Doi | 10.1038/ni.2402 |
| Citation | Rudra D, et al. (2012) Transcription factor Foxp3 and its protein partners form a complex regulatory network. Nat Immunol 13(10):1010-9 |
| abstractText | The transcription factor Foxp3 is indispensible for the differentiation and function of regulatory T cells (T(reg) cells). To gain insights into the molecular mechanisms of Foxp3-mediated gene expression, we purified Foxp3 complexes and explored their composition. Biochemical and mass-spectrometric analyses revealed that Foxp3 forms multiprotein complexes of 400-800 kDa or larger and identified 361 associated proteins, approximately 30% of which were transcription related. Foxp3 directly regulated expression of a large proportion of the genes encoding its cofactors. Some transcription factor partners of Foxp3 facilitated its expression. Functional analysis of the cooperation of Foxp3 with one such partner, GATA-3, provided additional evidence for a network of transcriptional regulation afforded by Foxp3 and its associates to control distinct aspects of T(reg) cell biology. |
