| First Author | Domenga V | Year | 2004 |
| Journal | Genes Dev | Volume | 18 |
| Issue | 22 | Pages | 2730-5 |
| PubMed ID | 15545631 | Mgi Jnum | J:94047 |
| Mgi Id | MGI:3510572 | Doi | 10.1101/gad.308904 |
| Citation | Domenga V, et al. (2004) Notch3 is required for arterial identity and maturation of vascular smooth muscle cells. Genes Dev 18(22):2730-5 |
| abstractText | Formation of a fully functional artery proceeds through a multistep process. Here we show that Notch3 is required to generate functional arteries in mice by regulating arterial differentiation and maturation of vascular smooth muscle cells (vSMC). In adult Notch3-/- mice distal arteries exhibit structural defects and arterial myogenic responses are defective. The postnatal maturation stage of vSMC is deficient in Notch3-/- mice. We further show that Notch3 is required for arterial specification of vSMC but not of endothelial cells. Our data reveal Notch3 to be the first cell-autonomous regulator of arterial differentiation and maturation of vSMC. |
