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Allele : Mre11a<tm1Jpt> MRE11A homolog A, double strand break repair nuclease; targeted mutation 1, John H J Petrini

Primary Identifier  MGI:3027036 Allele Type  Targeted
Attribute String  Humanized sequence Gene  Mre11a
Transmission  Germline Strain of Origin  129S7/SvEvBrd-Hprt1<b-m2>
Is Recombinase  false Is Wild Type  false
molecularNote  An A-to-T transversion point mutation was engineered at nucleotide 1894 of the coding sequence to recapitulate a nonsense mutation identified in human patients (codon 633). This mutation results in the truncation of 75 amino acids.
  • mutations:
  • Single point mutation
  • synonyms:
  • Mre11<ATLD1>,
  • Mre11<ATLD1>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

17 Publication categories

Trail: Allele