| First Author | Knobler RL | Year | 1984 |
| Journal | Exp Clin Immunogenet | Volume | 1 |
| Issue | 4 | Pages | 217-22 |
| PubMed ID | 6101098 | Mgi Jnum | J:14870 |
| Mgi Id | MGI:63028 | Citation | Knobler RL, et al. (1984) Host genetic control of mouse hepatitis virus type-4 (JHM strain) replication. II. The gene locus for susceptibility is linked to the Svp-2 locus on mouse chromosome 7. Exp Clin Immunogenet 1(4):217-22 |
| abstractText | Peritoneal macrophages were used to analyze host genetic control of MHV-4 infection in the 14 recombinant-inbred strains between susceptible SWR/J and resistant SJL/J progenitor strains. 4 strains were resistant to MHV-4 infection, while the remaining 10 strains were productively infected. Based upon the strain distribution pattern of susceptibility the gene locus for MHV-4 susceptibility is linked to the Svp-2 locus on the proximal end of mouse chromosome 7. This strain distribution pattern of susceptibility, and hence linkage, was determined to be identical for another MHV strain, MHV-A59. We have suggested that this locus-controlling susceptibility to MHV-4 and MHV-A59 be designated Hv-2. |
