| First Author | Mori L | Year | 1998 |
| Journal | Arthritis Rheum | Volume | 41 |
| Issue | 2 | Pages | 256-62 |
| PubMed ID | 9485083 | Mgi Jnum | J:134111 |
| Mgi Id | MGI:3785018 | Doi | 10.1002/1529-0131(199802)41:2<256::AID-ART9>3.0.CO;2-E |
| Citation | Mori L, et al. (1998) Genetic control of susceptibility to collagen-induced arthritis in T cell receptor beta-chain transgenic mice. Arthritis Rheum 41(2):256-62 |
| abstractText | OBJECTIVE: To study the genes in the mouse background which predispose to the development of collagen-induced arthritis (CIA). METHODS: T cell receptor beta transgenic (TCRbetaL) mice that have a T cell repertoire that predisposes to the development of CIA were used. Classic genetic studies and microsatellite gene mapping were done in (SWR-betaL x DBA/1)F2 hybrid mice. RESULTS: Besides TCRbeta, major histocompatibility complex class II, and Igh-C, at least 2 other genes are absolutely required for CIA development in these mice. A strict association of CIA with the presence of functional complement C5 allele (Hc1) was found, suggesting that Hc1 or a closely linked gene might be one of these essential genes. CONCLUSION: This study provides new evidence of the pathogenetic role of complement C5 in CIA. Furthermore, these transgenic mice may facilitate molecular identification of other genes that predispose to CIA. |
