| First Author | Tantin D | Year | 2005 |
| Journal | Cancer Res | Volume | 65 |
| Issue | 23 | Pages | 10750-8 |
| PubMed ID | 16322220 | Mgi Jnum | J:104090 |
| Mgi Id | MGI:3611127 | Doi | 10.1158/0008-5472.CAN-05-2399 |
| Citation | Tantin D, et al. (2005) The octamer binding transcription factor Oct-1 is a stress sensor. Cancer Res 65(23):10750-8 |
| abstractText | The POU-domain transcription factor Oct-1 is widely expressed in adult tissues and has been proposed to regulate a large group of target genes. Microarray expression profiling was used to evaluate gene expression changes in Oct-1-deficient mouse fibroblasts. A number of genes associated with cellular stress exhibited altered expression. Consistent with this finding, Oct-1-deficient fibroblasts were hypersensitive to gamma radiation, doxorubicin, and hydrogen peroxide and harbored elevated reactive oxygen species. Expression profiling identified a second group of genes dysregulated in Oct-1-deficient fibroblasts following irradiation, including many associated with oxidative and metabolic stress. A number of these genes contain octamer sequences in their immediate 5' regulatory regions, some of which are conserved in human. These results indicate that Oct-1 modulates the activity of genes important for the cellular response to stress. |
