| First Author | Liu O | Year | 2021 |
| Journal | iScience | Volume | 24 |
| Issue | 5 | Pages | 102446 |
| PubMed ID | 33997712 | Mgi Jnum | J:310082 |
| Mgi Id | MGI:6756274 | Doi | 10.1016/j.isci.2021.102446 |
| Citation | Liu O, et al. (2021) Adipose-mesenchymal stromal cells suppress experimental Sjogren syndrome by IL-33-driven expansion of ST2(+) regulatory T cells. iScience 24(5):102446 |
| abstractText | Adipose-derived mesenchymal stromal cells (ADSCs) play important roles in the alleviation of inflammation and autoimmune diseases. Interleukin-33 (IL-33), a member of the IL-1 family, has been shown to regulate innate and adaptive immunity. However, it is still unknown whether ADSCs regulate immune responses via IL-33. We show here that ADSCs produced IL-33 in response to IL-1beta stimulation, which depended on TAK1, ERK, and p38 pathways. ADSCs-derived IL-33 drove the proliferation of CD4(+)Foxp3(+)ST2(+) regulatory T cells (Tregs) and alleviated experimental autoimmune Sjogren syndrome in mice. Importantly, human ADSCs also produced IL-33 in response to IL-1beta. Thus, we have revealed a previously unrecognized immunoregulatory function of ADSCs by IL-33 production in experimental autoimmunity, which may have clinical applications for human immunopathology. |
