| First Author | Gupta VK | Year | 2010 |
| Journal | EMBO Rep | Volume | 11 |
| Issue | 11 | Pages | 861-7 |
| PubMed ID | 20890309 | Mgi Jnum | J:168152 |
| Mgi Id | MGI:4887285 | Doi | 10.1038/embor.2010.142 |
| Citation | Gupta VK, et al. (2010) Growth factor receptor-bound protein 14: a new modulator of photoreceptor-specific cyclic-nucleotide-gated channel. EMBO Rep 11(11):861-7 |
| abstractText | Growth factor receptor-bound protein 14 (Grb14) is an adaptor protein that is involved in receptor tyrosine kinase signalling. In this study, we report that Grb14 interacts with the rod photoreceptor-specific cyclic-nucleotide-gated channel alpha subunit (CNGA1) and decreases its affinity for cyclic guanosine monophosphate. Channel modulation is controlled by direct binding of the Grb14 Ras-associating domain with the carboxy-terminal region of CNGA1. We observed that the channel remains open in Grb14(-/-) mice that are exposed to light, suggesting that Grb14 is a normal physiological modulator of CNG channel function in vivo. |
