| First Author | Foretz M | Year | 2010 |
| Journal | FEBS Lett | Volume | 584 |
| Issue | 16 | Pages | 3667-71 |
| PubMed ID | 20670625 | Mgi Jnum | J:163593 |
| Mgi Id | MGI:4822487 | Doi | 10.1016/j.febslet.2010.07.041 |
| Citation | Foretz M, et al. (2010) Maintenance of red blood cell integrity by AMP-activated protein kinase alpha1 catalytic subunit. FEBS Lett 584(16):3667-71 |
| abstractText | AMP-activated protein kinase (AMPK) plays a pivotal role in regulating cellular energy metabolism. We previously showed that AMPKalpha1-/- mice develop moderate anemia associated with splenomegaly and high reticulocytosis. Here, we report that splenectomy of AMPKalpha1-/- mice worsened anemia supporting evidence that AMPKalpha1-/- mice developed a compensatory response through extramedullary erythropoiesis in the spleen. Transplantation of bone marrow from AMPKalpha1-/- mice into wild-type recipients recapitulated the hematologic phenotype. Further, AMPKalpha1-/- red blood cells (RBC) showed less deformability in response to shear stress limiting their membrane flexibility. Thus, our results highlight the crucial role of AMPK to preserve RBC integrity. |
