| First Author | Carrel L | Year | 1996 |
| Journal | Hum Mol Genet | Volume | 5 |
| Issue | 9 | Pages | 1361-6 |
| PubMed ID | 8872478 | Mgi Jnum | J:35234 |
| Mgi Id | MGI:82686 | Doi | 10.1093/hmg/5.9.1361 |
| Citation | Carrel L, et al. (1996) Tissue and lineage-specific variation in inactive X chromosome expression of the murine Smcx gene. Hum Mol Genet 5(9):1361-6 |
| abstractText | To understand how gene expression patterns are established on the inactive X chromosome during development, we have studied the murine gene Smcx, which is expressed from both the active and inactive mouse X chromosomes. In all tissues assayed, Smcx only partially escapes X inactivation, with expression levels from the inactive X allele similar to 30-65% that of the active X allele. Additionally, inactive X expression levels differed between extraembryonic and embryonic tissues and among different tissues from newborn and adult mice. Imprinted extraembryonic tissue had the lowest levels of inactive X Smcx expression, whereas the highest levels were in heart. These data suggest that the chromosomal basis of X inactivation differs among tissues, perhaps reflecting differences in the timing or regulation of inactivation in these cell lineages. |
