Primary Identifier | MGI:3033222 | Allele Type | Chemically induced (ENU) |
Gene | Gck | Inheritance Mode | Dominant |
Strain of Origin | C57BL/6J | Is Recombinase | false |
Is Wild Type | false | Project Collection | RIKEN GSC ENU Project |
molecularNote | G to T transversion in the first exon at a beta cell specific splice donor site (IVS1A+1) was found. No change in liver Gck mRNA expression, protein expression, or activity was detected. This same mutation is found in human MODY2 patients. |