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Allele : Gck<Rgsc210> glucokinase; RIKEN Genomic Sciences Center (GSC), 210

Primary Identifier  MGI:3033222 Allele Type  Chemically induced (ENU)
Gene  Gck Inheritance Mode  Dominant
Strain of Origin  C57BL/6J Is Recombinase  false
Is Wild Type  false Project Collection  RIKEN GSC ENU Project
molecularNote  G to T transversion in the first exon at a beta cell specific splice donor site (IVS1A+1) was found. No change in liver Gck mRNA expression, protein expression, or activity was detected. This same mutation is found in human MODY2 patients.
  • mutations:
  • Single point mutation
  • synonyms:
  • Rgsc210,
  • early onset diabetes, 2 RIKEN GSC,
  • Gck<1Rgsc>,
  • Rgsc210,
  • Gck<IVS1A+1G-T>,
  • Gck<1Rgsc>,
  • M-210,
  • Gck<IVS1A+1G-T>,
  • early onset diabetes, 2 RIKEN GSC,
  • M-210
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

4 Publication categories

Trail: Allele