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Allele : Gck<Rgsc341> glucokinase; RIKEN Genomic Sciences Center (GSC), 341

Primary Identifier  MGI:3033224 Allele Type  Chemically induced (ENU)
Gene  Gck Inheritance Mode  Dominant
Strain of Origin  C57BL/6J Is Recombinase  false
Is Wild Type  false Project Collection  RIKEN GSC ENU Project
molecularNote  G to A transition in exon 6 results in a missense mutation and substitution of tyrosine for cysteine at amino acid 220. Real time PCR detected no change in Gck mRNA expression however protein levels and Gck activity are reduced.
  • mutations:
  • Single point mutation
  • synonyms:
  • Gck<3Rgsc>,
  • early onset diabetes, 3 RIKEN GSC,
  • Gck<C220Y>,
  • Rgsc341,
  • early onset diabetes, 3 RIKEN GSC,
  • M-341,
  • Gck<C220Y>,
  • M-341,
  • Gck<3Rgsc>,
  • Rgsc341
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

4 Publication categories

Trail: Allele