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Allele : Gck<Rgsc475> glucokinase; RIKEN Genomic Sciences Center (GSC), 475

Primary Identifier  MGI:3033226 Allele Type  Chemically induced (ENU)
Gene  Gck Inheritance Mode  Dominant
Strain of Origin  C57BL/6J Is Recombinase  false
Is Wild Type  false Project Collection  RIKEN GSC ENU Project
molecularNote  C to A transversion in exon 7 results in a nonsense mutation and changes a Tyrosine into a stop at amino acid 273. Real time PCR and immunoblotting found decreased liver Gck mRNA, protein expression and Gck activity were reduced.
  • mutations:
  • Single point mutation
  • synonyms:
  • early onset diabetes, 5 RIKEN GSC,
  • Rgsc475,
  • M-475,
  • Gck<Y273Stop>,
  • Gck<5Rgsc>,
  • Rgsc475,
  • Gck<5Rgsc>,
  • Gck<Y273Stop>,
  • M-475,
  • early onset diabetes, 5 RIKEN GSC
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

4 Publication categories

Trail: Allele