Primary Identifier | MGI:3033226 | Allele Type | Chemically induced (ENU) |
Gene | Gck | Inheritance Mode | Dominant |
Strain of Origin | C57BL/6J | Is Recombinase | false |
Is Wild Type | false | Project Collection | RIKEN GSC ENU Project |
molecularNote | C to A transversion in exon 7 results in a nonsense mutation and changes a Tyrosine into a stop at amino acid 273. Real time PCR and immunoblotting found decreased liver Gck mRNA, protein expression and Gck activity were reduced. |