| First Author | Que LG | Year | 2005 |
| Journal | Science | Volume | 308 |
| Issue | 5728 | Pages | 1618-21 |
| PubMed ID | 15919956 | Mgi Jnum | J:105651 |
| Mgi Id | MGI:3616157 | Doi | 10.1126/science.1108228 |
| Citation | Que LG, et al. (2005) Protection from experimental asthma by an endogenous bronchodilator. Science 308(5728):1618-21 |
| abstractText | Mechanisms that protect against asthma remain poorly understood. S-nitrosoglutathione (GSNO), an endogenous bronchodilator, is depleted from asthmatic airways, suggesting a protective role. We report that, following allergen challenge, wild-type mice exhibiting airway hyperresponsivity have increased airway levels of the enzyme GSNO reductase (GSNOR) and are depleted of lung S-nitrosothiols (SNOs). In contrast, mice with genetic deletion of GSNOR exhibit increases in lung SNOs and are protected from airway hyperresponsivity. Our results indicate that endogenous SNOs, governed by GSNOR, are critical regulators of airway responsivity and may provide new therapeutic approaches to asthma. |
