| First Author | Prochazka M | Year | 1987 |
| Journal | Science | Volume | 237 |
| Issue | 4812 | Pages | 286-9 |
| PubMed ID | 2885918 | Mgi Jnum | J:8783 |
| Mgi Id | MGI:57248 | Doi | 10.1126/science.2885918 |
| Citation | Prochazka M, et al. (1987) Three recessive loci required for insulin-dependent diabetes in nonobese diabetic mice [published erratum appears in Science 1988 Nov 11;242(4880):945]. Science 237(4812):286-9 |
| abstractText | A polygenic basis for susceptibility to insulin-dependent diabetes in nonobese diabetic (NOD) mice has been established by outcross to a related inbred strain, nonobese normal (NON). Analysis of first and second backcross progeny has shown that at least three recessive genes are required for development of overt diabetes. One, Idd-1s, is tightly linked to the H-2K locus on chromosome 17; another, Idd-2s, is localized proximal to the Thy-1/Alp-1 cluster on chromosome 9. Segregation of a third, Idd-3s, could be shown in a second backcross. Neither Idd-1s nor Idd-2s could individually be identified as the locus controlling insulitis; leukocytic infiltrates in pancreas were common in most asymptomatic BC1 mice. Both F1 and BC1 mice exhibited the unusually high percentage of splenic T lymphocytes characteristic of NOD, suggesting dominant inheritance of this trait. The polygenic control of diabetogenesis in NOD mice, in which a recessive gene linked to the major histocompatibility complex is but one of several controlling loci, suggests that similar polygenic interactions underlie this type of diabetes in humans. |
