| First Author | Dewberry RM | Year | 2008 |
| Journal | FEBS Lett | Volume | 582 |
| Issue | 6 | Pages | 886-90 |
| PubMed ID | 18282478 | Mgi Jnum | J:133324 |
| Mgi Id | MGI:3778262 | Doi | 10.1016/j.febslet.2008.02.021 |
| Citation | Dewberry RM, et al. (2008) Interleukin-1 receptor antagonist (IL-1ra) modulates endothelial cell proliferation. FEBS Lett 582(6):886-90 |
| abstractText | Endothelial cell (EC) lifespan controlled by the IL-1 family of cytokines is an important determinant of susceptibility to artery wall disease. Here we show that EC lacking intracellular interleukin-1 receptor antagonist (IL-1ra) have a reduced lifespan compared to controls. Over expression of IL-1ra enhanced proliferation via cyclin dependent kinase 2 activity and retinoblastoma protein phosphorylation. This was not seen in EC lacking IL-1 receptor 1 (IL-1 signalling ability), nor apparent using other stimuli e.g. TNFalpha. These data suggest that IL-1ra has a specific and receptor-dependent function to control the growth and lifespan of EC. |
