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Allele : Tg(Th-MYCN)41Waw transgene insertion 41, William A Weiss
Primary Identifier  MGI:3039395 Allele Type  Transgenic
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Tg(Th-MYCN)41Waw
Strain of Origin  BALB/c and C57BL/6J Is Recombinase  false
Is Wild Type  false
description  Mice carrying this transgene on a 129X1/SvJ background are predisposed to neuroblastoma and show many of the features of the human childhood disease. Genomic analysis of tumors from these mice have shown allelic imbalance in chromosomal regions orthologous to those found in human neuroblastoma.
molecularNote  The rat tyrosine hydrolase promoter directs expression of human v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) (MYCN) to migrating cells of the neural crest during early development. Expression was found in the adrenal gland with marginal expression in brain, heart, testes and spleen.
  • mutations:
  • Insertion
  • synonyms:
  • Th-MYCN,
  • MYCN,
  • TH-NMYC,
  • MYCN,
  • Th-MYCN,
  • TH-NMYC
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1 Feature

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1 Expresses

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0 Mutation Involves

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2 Carried By

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1 Driven By

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