| First Author | Koujitani T | Year | 2000 |
| Journal | Cancer Lett | Volume | 152 |
| Issue | 2 | Pages | 211-6 |
| PubMed ID | 10773414 | Mgi Jnum | J:61989 |
| Mgi Id | MGI:1855850 | Doi | 10.1016/s0304-3835(00)00338-4 |
| Citation | Koujitani T, et al. (2000) Lack of susceptibility of transgenic mice carrying the human c-Ha-ras proto-oncogene (rasH2 mice) to phenolphthalein in a 6-month carcinogenicity study. Cancer Lett 152(2):211-6 |
| abstractText | Phenolphthalein has carcinogenic activity, causing malignant lymphomas in B6C3F1 mice at a dietary dose of 3000 ppm in a 2-year carcinogenicity study and in heterozygous p53-deficient female mice at the same dose in a 6-month study. To examine whether phenolphthalein carcinogenic potential can be detected in male and female transgenic (Tg) mice carrying the human c-Ha-ras gene (rasH2 mice) and their wild-type littermates (non-Tg mice), a diet containing 3000, 6000 or 12000 ppm was given for 6 months. Unequivocal induction of neoplastic lesions was not apparent, suggesting that rasH2 mice are resistant to the induction of malignant lymphomas by the treatment of phenolphthalein. |
