| First Author | Tremblay PJ | Year | 1989 |
| Journal | Mol Cell Biol | Volume | 9 |
| Issue | 2 | Pages | 854-9 |
| PubMed ID | 2540427 | Mgi Jnum | J:46456 |
| Mgi Id | MGI:1199233 | Doi | 10.1128/mcb.9.2.854 |
| Citation | Tremblay PJ, et al. (1989) Transgenic mice carrying the mouse mammary tumor virus ras fusion gene: distinct effects in various tissues. Mol Cell Biol 9(2):854-9 |
| abstractText | Transgenic mice carrying the v-Ha-ras oncogene under the control of the mouse mammary tumor virus long terminal repeat were produced. These mice exhibit several phenotypes: mammary tumors, bilateral hyperplasia of the harderian lacrimal gland, primary bronchio-alveolar lung adenocarcinoma, and splenomegaly. High levels of the transgene RNA were detected in mammary, harderian, and lung tumors. Accumulation of cells of the myeloid lineages was found in enlarged spleens. This phenotype may represent an indirect effect of v-Ha-ras expression on myeloid progenitors. Our data illustrate the cell-specific effects of v-Ha-ras. |
