| First Author | Stumhofer JS | Year | 2010 |
| Journal | Nat Immunol | Volume | 11 |
| Issue | 12 | Pages | 1119-26 |
| PubMed ID | 21057510 | Mgi Jnum | J:167324 |
| Mgi Id | MGI:4867800 | Doi | 10.1038/ni.1957 |
| Citation | Stumhofer JS, et al. (2010) A role for IL-27p28 as an antagonist of gp130-mediated signaling. Nat Immunol 11(12):1119-26 |
| abstractText | The heterodimeric cytokine interleukin 27 (IL-27) signals through the IL-27Ralpha subunit of its receptor, combined with gp130, a common receptor chain used by several cytokines, including IL-6. Notably, the IL-27 subunits p28 (IL-27p28) and EBI3 are not always expressed together, which suggests that they may have unique functions. Here we show that IL-27p28, independently of EBI3, antagonized cytokine signaling through gp130 and IL-6-mediated production of IL-17 and IL-10. Similarly, the ability to generate antibody responses was dependent on the activity of gp130-signaling cytokines. Mice transgenic for expression of IL-27p28 showed a substantial defect in the formation of germinal centers and antibody production. Thus, IL-27p28, as a natural antagonist of gp130-mediated signaling, may be useful as a therapeutic for managing inflammation mediated by cytokines that signal through gp130. |
