Primary Identifier | MGI:3042111 | Allele Type | Targeted |
Attribute String | Conditional ready, Hypomorph | Gene | Arnt |
Transmission | Germline | Strain of Origin | 129/Sv |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A global hypomorphic Arnt allele was generated by inserting a neo cassette flanked by Loxp sites 3' of exon 6, which encodes the basic helix-loop-helix domain. A third loxp site was inserted 5' of exon 6. Western blot analysis confirmed decreased Arnt expression in all tissues examined from homozygous mice. |