| First Author | Lasar D | Year | 2018 |
| Journal | Cell Rep | Volume | 22 |
| Issue | 3 | Pages | 760-773 |
| PubMed ID | 29346772 | Mgi Jnum | J:270759 |
| Mgi Id | MGI:6278694 | Doi | 10.1016/j.celrep.2017.12.067 |
| Citation | Lasar D, et al. (2018) Peroxisome Proliferator Activated Receptor Gamma Controls Mature Brown Adipocyte Inducibility through Glycerol Kinase. Cell Rep 22(3):760-773 |
| abstractText | Peroxisome proliferator-activated receptors (PPARs) have been suggested as the master regulators of adipose tissue formation. However, their role in regulating brown fat functionality has not been resolved. To address this question, we generated mice with inducible brown fat-specific deletions of PPARalpha, beta/delta, and gamma, respectively. We found that both PPARalpha and beta/deltadelta are dispensable for brown fat function. In contrast, we could show that ablation of PPARgamma in vitro and in vivo led to a reduced thermogenic capacity accompanied by a loss of inducibility by beta-adrenergic signaling, as well as a shift from oxidative fatty acid metabolism to glucose utilization. We identified glycerol kinase (Gyk) as a partial mediator of PPARgamma function and could show that Gyk expression correlates with brown fat thermogenic capacity in human brown fat biopsies. Thus, Gyk might constitute the link between PPARgamma-mediated regulation of brown fat function and activation by beta-adrenergic signaling. |
