| First Author | Hasegawa K | Year | 2004 |
| Journal | Science | Volume | 303 |
| Issue | 5658 | Pages | 685-9 |
| PubMed ID | 14752163 | Mgi Jnum | J:90029 |
| Mgi Id | MGI:3042327 | Doi | 10.1126/science.1092138 |
| Citation | Hasegawa K, et al. (2004) PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells. Science 303(5658):685-9 |
| abstractText | Protein tyrosine kinases and phosphatases cooperate to regulate normal immune cell function. We examined the role of PEST domain-enriched tyrosine phosphatase (PEP) in regulating T cell antigen-receptor function during thymocyte development and peripheral T cell differentiation. Although normal naive T cell functions were retained in pep-deficient mice, effector/memory T cells demonstrated enhanced activation of Lck. In turn, this resulted in increased expansion and function of the effector/memory T cell pool, which was also associated with spontaneous development of germinal centers and elevated serum antibody levels. These results revealed a central role for PEP in negatively regulating specific aspects of T cell development and function. |
