| First Author | Maine CJ | Year | 2012 |
| Journal | J Immunol | Volume | 188 |
| Issue | 11 | Pages | 5267-75 |
| PubMed ID | 22539785 | Mgi Jnum | J:188743 |
| Mgi Id | MGI:5441683 | Doi | 10.4049/jimmunol.1200150 |
| Citation | Maine CJ, et al. (2012) PTPN22 alters the development of regulatory T cells in the thymus. J Immunol 188(11):5267-75 |
| abstractText | PTPN22 encodes a tyrosine phosphatase that inhibits Src-family kinases responsible for Ag receptor signaling in lymphocytes and is strongly linked with susceptibility to a number of autoimmune diseases. As strength of TCR signal is critical to the thymic selection of regulatory T cells (Tregs), we examined the effect of murine PTPN22 deficiency on Treg development and function. In the thymus, numbers of pre-Tregs and Tregs increased inversely with the level of PTPN22. This increase in Tregs persisted in the periphery and could play a key part in the reduced severity observed in the PTPN22-deficient mice of experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis. This could explain the lack of association of certain autoimmune conditions with PTPN22 risk alleles. |
